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KMID : 1134820170460121462
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Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 12 p.1462 ~ p.1467
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Effect of Diosmin on Osteoblast Differentiation
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Kim Kyeong-Min
Jang Won-Gu
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Abstract
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Diosmin is a compound that is widely distributed in citrus. The aim of this study was to examine the effects of diosmin on osteoblast differentiation using MC3T3-E1 preosteoblast cells. The effect of diosmin on mRNA expression levels of osteogenic genes in MC3T3E1 cells were determined by RT-PCR. Diosmin regulated expression of key osteogenic genes such as dNA-binding protein inhibitor (Id1), runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP), and osteocalcin (OC) during osteoblast differentiation, and promoted recovery of tumor necrosis factor (TNF)-α-reduced osteogenesis. Alizarin Red S staining was performed to evaluate mineralization. Diosmin enhanced mineralization and recovery of TNF-α-reduced osteoblast differentiation. These results suggest that diosmin may enhance osteoblast differentiation and recovery of TNF-α-reduced osteoblast differentiation, and it may be a candidate for treating osteoporosis.
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KEYWORD
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diosmin, osteoblast differentiation, preosteoblast, mineralization, TNF-α
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